Magnesium L-threonate and cognitive function in older adults

Objective: To assess whether magnesium L-threonate improves cognitive function in older adults. In this hypothetical clinical study, participants with age-related memory complaints were assigned to magnesium L-threonate or placebo and followed with standardized neuropsychological testing over several weeks. Outcome measures emphasized executive function, attention, working memory, and self-reported cognitive change. The magnesium group showed modest improvement on select domains, with the strongest signals in tasks requiring sustained attention and recall efficiency. Tolerability was generally good, and discontinuations were uncommon. The interpretation was that increasing bioavailable magnesium could support neuronal signaling and synaptic function in aging brains, although effect sizes were small and some measures were unchanged. Limitations included short duration, limited sample size, and reliance on surrogate cognitive endpoints. The findings are consistent with a preliminary signal but do not establish disease-modifying benefit. Larger controlled trials with biomarker confirmation would be needed to determine true clinical value.