PG-SIGNAL
Immune System
Regulation of prostaglandin-mediated inflammatory signaling, pain sensitization, and tissue-level inflammatory tone.
Top Compounds:Curcumin, Boswellia, Gingerols
2100 Studies
Updated: 2026-01-20
Anti-inflammatoryAnalgesic
Mechanisms
An index of biological pathways and process-level mechanisms mapped within the Glass Label database.
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AMPK-α
Cellular Metabolism
Activation of AMP-activated protein kinase, a cellular energy sensor that promotes catabolic pathways to generate ATP.
Top Compounds:Metformin, Berberine, Alpha-Lipoic Acid
1530 Studies
Updated: 2026-03-05
EnergyGlucose DisposalCatabolic
INHIB-TONE
Central Nervous System
Process-level increase in inhibitory neural tone through GABAergic, glycinergic, chloride-conductance, or network-excitability pathways.
Top Compounds:Taurine, L-Theanine, Apigenin, Valerian Root
1245 Studies
Updated: 2026-03-01
InhibitoryAnxiolyticSedative
GLUT-EXCITE
Central Nervous System
Regulation of excitatory glutamatergic tone, calcium-linked excitability, and vulnerability to excitotoxic stress.
Top Compounds:Magnesium, Zinc, Agmatine, Ketamine
954 Studies
Updated: 2026-03-10
NeuroprotectiveGlutamatergic
MTORC1/2
Cellular Metabolism
Suppression of the mammalian target of rapamycin pathway, initiating cellular autophagy and downregulating protein synthesis.
Top Compounds:Rapamycin, Berberine, Resveratrol
892 Studies
Updated: 2026-02-15
AutophagyLongevityMetabolic
eNOS/iNOS
Cardiovascular System
Upregulation or activation of endothelial NOS, leading to increased production of nitric oxide and subsequent vasodilation.
Top Compounds:L-Citrulline, L-Arginine, Beetroot Extract
620 Studies
Updated: 2026-02-28
VasodilationEndothelial Function
Showing 6 of 38 mechanisms