Magnesium L-Threonate
My Stack

I. Abstract

Magnesium L-threonate is a magnesium salt of L-threonic acid, modeled here as a compound form whose practical identity is tied to magnesium delivery and brain-focused cognitive support rather than a novel active molecule separate from magnesium.

In the mock evidence graph, its strongest signals are organized around brain magnesium, glutamatergic excitability, synaptic plasticity, sleep quality, and duplicate magnesium exposure risk. This makes it a useful test case for compound forms, active moieties, and mineral duplicate-exposure warnings.

Clinical Summary

Primary Efficacy
  • — Supports cognitive-aging and synaptic-plasticity hypotheses through brain magnesium context.
  • — May support sleep quality indirectly through magnesium status and nervous-system excitability.
Studied Dose Context
Cognitive support
1g - 2g Daily Evening
Sleep-adjacent use
1g Daily 1-2h before bed
Key Cautions
  • — Renal impairment
  • — Duplicate magnesium

II. Activity Profile

Effects

documented physiological and clinical outcomes, ranked by evidence strength and magnitude

Cognitive SupportCOGNITION

Magnesium L-threonate is modeled as a brain-focused magnesium form associated with learning, memory, and age-related cognitive support.

Evidence: Medium·Magnitude: Low to moderate
Sleep Quality ImprovementSLEEP

May support sleep quality indirectly through magnesium status and nervous-system excitability.

Evidence: Low·Magnitude: Low
Neuroplasticity SupportNEURAL

Associated with synaptic density and plasticity markers in preclinical and translational models.

Evidence: Medium·Magnitude: Moderate

III. Dose Evidence

Target Range
1g - 2g
Frequency
Daily
Timing
Evening
Clinical Notes

Brain-focused magnesium form used in cognitive-support and synaptic-plasticity contexts.

Dietary Sources
Supplemental magnesium L-threonate
~144mg elemental magnesium/ standard serving
Endogenous handling

Magnesium is an essential mineral and is not synthesized endogenously. Magnesium L-threonate is a supplemental salt form; endogenous handling concerns magnesium homeostasis, absorption, and renal excretion rather than biosynthesis.

IV. Safety Context

Safety context is scoped to the cited records and may change as the evidence review evolves.

Upper Limit
Not established for this form
Observed Safe
1g - 2g/day supplemental form in mock study contexts
NOAEL
Not established in this record
Half-Life
Not well characterized
Elimination
Renal magnesium handling

Generally tolerated at common supplemental doses; total magnesium exposure matters more than the L-threonate label alone.

V. Related Compounds

Effects

Compounds related by overlapping physiological or clinical outcomes.

Taurine
Shared Target
Shared Effects: Cognitive Support, Neuroprotection
L Theanine
Commonly Stacked
Shared Effects: Sleep Quality Improvement

VI. Key Studies

Curated source records that explain the evidence landscape for this compound, including endpoint evidence, mechanism anchors, dose context, safety context, and limiting evidence.