Neuroprotective effects of taurine supplementation

Background: Taurine has been investigated for neuroprotective properties in experimental models of brain injury, neurodegeneration, and inflammatory stress. We assessed the effects of taurine supplementation on behavioral and tissue-level outcomes in preclinical models, with attention to neuroinflammatory signaling, oxidative injury, and cognitive performance. Across the included experiments, taurine exposure was associated with reductions in glial activation, lower inflammatory cytokine expression, and preservation of neuronal structure in vulnerable regions. Several models also reported improved performance on memory- and learning-related tasks, particularly when taurine was administered before or during the period of neural insult. The overall pattern suggests that taurine may buffer excitotoxic and inflammatory cascades while supporting cellular resilience. However, outcomes differed by model type, injury paradigm, and dosing schedule, and publication bias could not be excluded. These data support a biologically plausible neuroprotective signal that merits confirmation in carefully designed translational studies.