Human taurine pharmacokinetics and renal handling

Objective: To characterize human taurine pharmacokinetics and renal handling after controlled oral exposure. Healthy volunteers received taurine in standardized doses, and serial blood and urine samples were analyzed to estimate plasma concentration-time profiles, elimination kinetics, and fractional excretion. Taurine was absorbed predictably, reached peak circulating concentrations within a narrow post-dose window, and exhibited elimination consistent with efficient renal clearance and homeostatic regulation. Individuals with higher baseline intake or distinct renal handling showed modest variation in exposure, but overall interparticipant variability was moderate. The data suggest that taurine has a relatively short systemic residence time and that circulating levels are tightly controlled by renal reabsorption and excretion mechanisms. No serious safety signals were observed under the conditions studied. These results provide a practical basis for dose selection in human trials and help interpret biomarker studies that use taurine concentration as a proxy for intake or physiologic status.