Other

Other safety context

Rapid increases in running, cycling, or other repetitive aerobic load can exceed tissue tolerance even when intensity is moderate.

Human evidence

Aerobic volume becomes harder to interpret when sleep, energy intake, illness, or recovery capacity are poor.

Mixed evidence

Exposure tolerance should be treated as an implementation variable; shorter and less intense sessions are more defensible starting contexts than maximal heat stress.

Mixed evidence
Elderly individualsInformational

Endogenous synthesis and tissue levels may decline with age.

Human evidence
Premature infantsInformational

Immature biosynthetic capacity; higher taurine requirements during development.

Clinical review