SIMPLE COMPOUNDS
Sleep Onset Support
Sleep Onset Support is indexed as a partial Melatonin effect from the compound directory seed.
Evidence: Not Assessed
Magnitude: Not Assessed
I. Abstract
Endogenous circadian hormone and supplement/drug boundary case used to test regulatory variation and sleep-specific identity.
II. Activity Profile
Effects
documented physiological and clinical outcomes, ranked by evidence strength and magnitude
Sleep Onset SupportSIMPLE COMPOUNDS
Sleep Onset Support is indexed as a partial Melatonin effect from the compound directory seed.
Evidence: Not Assessed·Magnitude: Not Assessed
Circadian Phase ShiftSIMPLE COMPOUNDS
Circadian Phase Shift is indexed as a partial Melatonin effect from the compound directory seed.
Evidence: Not Assessed·Magnitude: Not Assessed
SIMPLE COMPOUNDS
Circadian Phase Shift
Circadian Phase Shift is indexed as a partial Melatonin effect from the compound directory seed.
Evidence: Not Assessed
Magnitude: Not Assessed
III. Dose Evidence
Target Range
0.3mg - 3mg
Frequency
As needed
Timing
30-90 min before bed
Clinical Notes
Dose and timing are more important than total daily exposure for circadian use.
Dietary Sources
Trace dietary sources
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Endogenous synthesis
Melatonin is synthesized endogenously from serotonin in circadian pineal signaling pathways, while supplemental melatonin introduces exogenous exposure.
VI. Key Studies
Curated source records that explain the evidence landscape for this compound, including endpoint evidence, mechanism anchors, dose context, safety context, and limiting evidence.
| Year | Literature | Evidence Role | Uses |
|---|---|---|---|
| 2019 | L-theanine in the adjunctive treatment of anxiety disorder Glass Label et al.·Journal of Clinical Psychiatry | background biology | 0 |