Ashwagandha Extract
My Stack

I. Abstract

Ashwagandha extract is a botanical extract derived from Withania somnifera root. The entity is modeled as an extract rather than a single molecule because preparation type, plant part, and withanolide-containing standardization are central to interpretation.

The mock monograph organizes ashwagandha around stress support, cortisol modulation, sleep quality, HPA-axis signaling, and extract-specific safety issues such as thyroid-sensitive contexts and rare liver injury signals.

Clinical Summary

Primary Efficacy
  • — Associated with lower perceived stress and cortisol modulation in standardized extract contexts.
  • — May support sleep quality when stress burden is a major driver of sleep disruption.
Studied Dose Context
Standardized root extract
300mg - 600mg Daily With food
Sleep / stress support
300mg Daily Evening
Key Cautions
  • — Pregnancy
  • — Thyroid-sensitive contexts
  • — Rare liver injury signals

II. Activity Profile

Effects

documented physiological and clinical outcomes, ranked by evidence strength and magnitude

Stress ReductionSTRESS

Ashwagandha extract is modeled as a stress-support botanical with HPA-axis and subjective-stress endpoints.

Evidence: Medium·Magnitude: Moderate
Sleep Quality ImprovementSLEEP

May improve sleep quality and recovery in stress-associated sleep disruption contexts.

Evidence: Medium·Magnitude: Low to moderate
Cortisol ModulationENDOCRINE

Modeled as cortisol-modulating rather than simply cortisol-lowering across all contexts.

Evidence: Medium·Magnitude: Moderate

III. Dose Evidence

Target Range
300mg - 600mg
Frequency
Daily
Timing
With food
Clinical Notes

Common standardized extract range for stress-support contexts.

Dietary Sources
Withania somnifera root extract
/
Exogenous botanical exposure

Ashwagandha extract is botanical and is not synthesized endogenously. Internal exposure depends on extract composition, absorption, metabolism of withanolides, and hepatic handling of botanical constituents.

IV. Safety Context

Safety context is scoped to the cited records and may change as the evidence review evolves.

Upper Limit
Not established for standardized extracts
Observed Safe
300mg - 600mg/day standardized extract in mock study contexts
NOAEL
Not established in this record
Half-Life
Not well characterized
Elimination
Hepatic and biliary handling
Metabolism
Hepatic handling of botanical constituents

Generally tolerated in short-term standardized extract trials, with botanical-specific cautions for pregnancy, thyroid-sensitive contexts, and rare liver injury signals.

V. Related Compounds

Effects

Compounds related by overlapping physiological or clinical outcomes.

Apigenin
Shared Effect
Shared Effects: Sleep Quality Improvement, Stress Reduction
L Theanine
Functional Analog
Shared Effects: Stress Reduction, Anxiolysis

VI. Key Studies

Curated source records that explain the evidence landscape for this compound, including endpoint evidence, mechanism anchors, dose context, safety context, and limiting evidence.