SLEEP
Sleep Latency Reduction
Apigenin is not represented as a strong hypnotic; the seed treats it as mild sleep-associated flavone activity.
Evidence: Low
Magnitude: Low
I. Abstract
Apigenin is a plant-derived flavone found in foods and botanicals such as parsley, chamomile, and celery. In Glass Label it is modeled as a simple plant-derived compound with sleep-associated, calming, and cellular-maintenance contexts.
The seeded evidence graph distinguishes mild GABA-A-linked sleep/anxiolysis context from a separate CD38/NAD+ mechanistic hypothesis. This makes apigenin useful for testing how a compound can have both practical sleep use and more speculative cellular mechanisms.
Clinical Summary
Primary Efficacy
- — Mild sleep-latency support through GABAergic and calming-context mechanisms.
- — Mechanistic CD38/NAD+ context included as a cellular-maintenance hypothesis.
Studied Dose Context
Sleep support
25mg - 50mg As needed Evening
Dietary flavone context
food-level exposure Dietary With meals
Key Cautions
- — Sedatives and alcohol
II. Activity Profile
Effects
documented physiological and clinical outcomes, ranked by evidence strength and magnitude
Apigenin is not represented as a strong hypnotic; the seed treats it as mild sleep-associated flavone activity.
Evidence: Low·Magnitude: Low
AnxiolysisMOOD
Associated with calming and anxiolytic-like activity in mechanistic and preclinical models.
Evidence: Low·Magnitude: Low
Nad MaintenanceCELLULAR
Linked to CD38/NAD+ maintenance in mechanistic seed data.
Evidence: Low·Magnitude: Uncertain
MOOD
Anxiolysis
Associated with calming and anxiolytic-like activity in mechanistic and preclinical models.
Evidence: Low
Magnitude: Low
CELLULAR
Nad Maintenance
Linked to CD38/NAD+ maintenance in mechanistic seed data.
Evidence: Low
Magnitude: Uncertain
III. Dose Evidence
Target Range
25mg - 50mg
Frequency
As needed
Timing
Evening
Clinical Notes
Mild sleep-support seed for apigenin's GABAergic flavone context.
Dietary Sources
Parsley
~45mg/ 100g
Chamomile infusion
~2mg/ cup
Celery
~3mg/ 100g
Dietary flavone exposure
Apigenin is a dietary flavone and is not synthesized endogenously. Internal exposure depends on dietary intake, intestinal absorption, conjugation, and hepatic metabolism.
IV. Safety Context
Safety context is scoped to the cited records and may change as the evidence review evolves.
V. Related Compounds
Effects
Compounds related by overlapping physiological or clinical outcomes.
L Theanine
Shared Mechanism
Shared Effects: Anxiolysis, Sleep Latency Reduction
Shared Mechanism
L Theanine
Shared Effects:
Anxiolysis,Sleep Latency Reduction
VI. Key Studies
Curated source records that explain the evidence landscape for this compound, including endpoint evidence, mechanism anchors, dose context, safety context, and limiting evidence.
| Year | Literature | Evidence Role | Uses |
|---|---|---|---|
| 2017 | Apigenin, GABAergic signaling, and sleep-related behavior Glass Label et al.·Molecular Nutrition & Food Research | mechanistic supportdirect endpoint evidencebackground biologysafety contextdose context | 9 |
| 2018 | Apigenin as a CD38 inhibitor in NAD metabolism models Glass Label et al.·Biochemical Pharmacology | mechanistic supportbackground biology | 4 |
| 2020 | Dietary sources and bioavailability of apigenin-rich foods Glass Label et al.·Food Chemistry | composition contextdose contextsafety context | 2 |